LGD4033 (Ligandrol)

LGD4033 (Ligandrol)

LGD-4033, also known as Ligandrol, is a type of chemical called a selective androgen receptor modulator (SARM) that mimics the activity of testosterone in the body. It was developed to address concerns about potential adverse effects of testosterone on the prostate by displaying tissue-selective activation of androgenic signaling1.

Safety and Tolerability

• LGD-4033 was well tolerated in a placebo-controlled study with 76 healthy men. There were no drug-related serious adverse events, and the frequency of adverse events was similar between active and placebo groups. The compliance was 100% among men included in the efficacy analysis1.

Pharmacokinetics

• LGD-4033 displayed a prolonged elimination half-life and dose-proportional accumulation upon multiple dosing. It also showed dose-dependent suppression of total testosterone, sex hormone-binding globulin, high density lipoprotein cholesterol, and triglyceride levels. However, hormone levels and lipids returned to baseline after treatment discontinuation1.

Effects

• LGD-4033 administration was associated with dose-dependent increase in lean body mass, but fat mass did not change significantly. It also resulted in significant suppression of certain hormones at the highest dose of 1.0 mg1.

Uses and Precautions

• Ligandrol is used to increase energy, improve athletic performance, and increase muscle growth, but it is banned by the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA). When taken by mouth, it is considered possibly unsafe for most people and may lead to side effects such as liver damage, heart attack, and stroke. It is also considered possibly unsafe during pregnancy and breastfeeding2.

In conclusion, LGD-4033 (Ligandrol) has shown favorable safety and tolerability profiles, with potential benefits in increasing lean body mass, but it is important to be aware of its potential risks, especially in relation to its use in sports and athletic performance12.

LGD-4033 (Ligandrol) is a chemical compound of a class of compounds known as SARM (Selective Androgen Receptor Modulator), a drug designed to facilitate strength and muscle building, enhance the burning of body fat and promote the increase of the user’s physical endurance.

Ligandrol, or LGD-4033, is a selective androgen receptor modulator (SARM) created by Ligand Pharmaceuticals. The active ingredient in LGD-4033 is anabolic, meaning that it works to build muscle and increase strength. It is mainly composed of two key ingredients, which are Ostarine and Andarine.

The usual dose of LGD 4033 for the best results is 5-10 mg daily; this is the dosage for men. The cycle duration is around 6-10 weeks, if you are a beginner then you should start with the minimum cycle length. Females should take Ligandrol in half the dosage as men for maximum 8 weeks time period.